1. intr. To be hateful, odious, offensive, or a cause of trouble (to, or with dat.) Obs.
2. trans. To be hateful or distasteful to; to trouble, irk, bore, weary. (= Fr. ennuyer.) In passive const. w. of. Obs.
b. impers. it annoys me..: it irks me. Obs. rare.
3. trans. To affect (a person) in a way that disturbs his equanimity, hurts his susceptibilities, or causes slight irritation. (Refers to the feeling produced, rather than to the action producing it; hence commonest in the passive to be annoyed: to be ruffled in mind, troubled, vexed.)
b. to be annoyed after or for: to worry about, be anxious for. Obs. rare.
c. refl. To vex oneself, take offence, grieve. Obs.
d. intr. (refl. pron. omitted.) Obs.
4. By transf. to the objective means: To molest, injure, hurt, harm; now esp. in military use.
5. To affect (a thing) in a way which interferes with its proper action; to interfere with detrimentally, affect injuriously. Obs.
-Oxford English Dictionary